Introduction of Coenzyme A
Coenzyme A, consisting of pantothenic acid, cysteine and phosphoadenosine diphosphate, exists largely in tissues and cells of living organism. It's critical role as an acryl carrier can de found in the metabolism of carbohydrates, lipid and protein (such as synthesis of acethylcholine, glycogen storage and metabolic regulation of cholesterol and other lipids). It' sphysical and biochemical functions can de used in the clinical treatments.
Biochemical Functions of Coenzyme A
1. Involve energy production: metabolic processes that facilitated more than 70 chemical reactions. Coenzyme A initiater the tricarboxylic acid cycle which produces more than 90 percent of the body' s energy. It also increases the fat utilization mechanism and amino acid catabolism.
2. provide active substances: Coenzyme A participates in the synthesis of many essential substances . In the brain , it involves the synthesis of neuromuscular messengers, neurotransmitters such as acetylcholine and melatonin which helps sleeping . Neuromuscular messengers function the communication between nerves and muscles . Neurotransmitters communicate the feeling. vitro stimulus ,memory between nerve and brain.
3. Transfer acryl group: Coenzyme A as an acryl carrier involves the acryl group transfer.
4. Strengthen the immune system: Coenzyme A involves toxic substance excretion, white blood cells activation, haemoglobin synthesis, and antibodies synthesis.
5. Facilitate the manufacture and repairment of connective tissue: Coenzyme A has critical roles in the cartilage Development, protection and repairment by facilitating the synthesis of chondroitin sulfate and hyaluronic acid.
6. Other functions: Coenzyme A enhances the utility of Coenzyme Q10 and Coenzyme I. It also can lower the side effdcts of antibiotic and other medicines.
Appllcation of Coenzyme A
Coenzyme A is mainly used to assist the therapy of lipid metabolic disorder and othet diseases:
1.Treatment of fatty liver and hyperlipoproteinemia: the health Center of Aoyama Gakuin University, Tokyo, Japan, Coenzyme A was used to treat the fatty live patients and got very good curative effect . Clinical treatments showed Coenzyme A is very efficient and has no side effects to IIA, IIB, IV types hyperlipoproteinemia, and hyperlipoproteinemia caused by diabetes, cerebral infarction, and menopause women.
2.Treatment of Arrhythmia and Cardiac Ischemia: Pantethine can increase the amount of ATP in cardiac muscle .So oral pantethine is effective to arrhythmia by extending active potential interval and effective refractory period. Pantethine also relieve chest pain and cardiac ischemia symptoms because it can alter the metabolism of hemodynamics parameter, lipid, riboflavin and vitamin C.
3.Treatment of obesity: Due to over-fed nutrition and physical work reduction, over weighted people in the world increase. Oral pantethine can lose body weight and won't cause hunger feeling from diet It also can decrease the possibility of ketosis caused by a high rate of fatty acid oxidation.
4.Treatment of sudden deafness: Sudden deafness is often caused by virus(mumps, measles, influenza virus, etc.) infection. Viruses can cause ear micro circulative dysfunction. Coenzyme A can relieve the symptoms caused by metabolic disorder.
5.A dietary supplement of nutritional source and hesath: Healthy people taking coenzyme-A can maintain the metabolic balance; prevent the diseases caused by metabolic disorder caused by metabolic disorder and keep them healthy . Coenzyme A Technologies Inc. USA manufactures a series of products in which pantethine and pantothenic acid are main ingredients. The products include Coenzyme-A which can maintain metabolic balance and prohibit coenzyme deficiency, Healthy Cholesterol Imagine which can lower the concentration of body cholesterol; Body image which can strengthen the immune system; Healthy joint Imagine which can relieve the symptoms caused byarthritis; Coenzyme-Serum, pigmentary deposits on the skin